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KMID : 1123920080220040896
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 4 p.896 ~ p.902
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Facilitated Axonal Regeneration of Injured Sciatic Nerves by Yukmijihwang-tang Treatment
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Kim Jung-Hyun
Seol In-Chan
Ryu Ho-Ryong
Jo Hyun-Kyung
An Joung-Jo
Namgung Uk
Kim Yoon-Sik
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Abstract
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Yukmijihwang-tang(YM) is used in Oriental medicine for treatments of diverse systemic symptoms including neurological dosorders. The present study was performed to examine potential effects of YM on growth-promoting activity of injured sciatic nerve axons. YM treatment in the injured sciatic nerve induced enhanced distal elongation of injured axons when measured 3 and 7 days after injury. Retrograde tracing of sciatic nerve axons showed YM-mediated increases in the number of DiI-labeled dorsal root ganglion (DRG) sensory neurons and spinal cord motor neurons at 3 days after injury. Hoechst nuclear staining showed that non-neuronal cell population was largely elevated by YM treatment in distal nerve area undergoing axonal regeneration. Furthermore, phospho-Erk1/2 protein levels were upregulated by YM treatment in the injured nerve area. These data suggest that YM may play a role in facilitated axonal regeneration in injured peripheral nerves. Further investigations of individual herbal components would be useful to explore effective molecular components and develop therapeutic strategies.
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KEYWORD
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Yukmijihwang-tang(YM), axonal regeneration, sciatic nerve, Erk1/2
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